How to use Rogaine topical

Read and follow all directions on the merchandise package before exploitation of this product. If you're unsure concerning any of the data, consult your doctor or pill pusher.

Clean and dry the scalp space before applying the medication. you will apply this product to damp hair. To use the answer, fill the device or the applicator with one ml = 1cubic centimeter of medication (to the one cubic centimeter line), or use twenty drops. half your hair within the space of dilution and apply the answer equally to the affected space of the scalp. Gently rub in. enable the solution to dry fully before the use of alternative merchandise (gels, mousse...) or before getting to bed.

To use the froth, rinse your hands in cold water and dry well. Apply concerning 1/2 containerful of froth to the scalp and rub in gently. permit the froth to dry fully before styling or about to bed.

If scalp irritation could be a downside, you will have to avoid treatment with minoxidil on identical days that you simply have your hair coloured or with chemicals treated (ex: permed).

Do not use on alternative elements of the body unless directed by your doctor. don't use on skin that's red, painful, irritated, scraped, cut, or infected. Wash hands completely when application. Avoid obtaining the medication in your eyes. If this happens, rinse your eyes with massive amounts of cool water.

Do not use this medication a lot of usually, apply additional of it than as directed, or apply it to associate irritated or sunburnt scalp. Doing thus will cause the drug to be absorbed into your body and lead to serious facet effects. This product could contain alcohol and might be irritating and drying to the scalp. raise your doctor or health professional or pharmacist the way to use this product safely.

It takes time for hair to grow again. the majority of people have to use this medication frequently for four months to check profit. This medication should be used unceasingly to keep up hair growth. If your condition doesn't improve or worsens when the use of this medication for four to six months, or if you're thinking that you will have a significant medical side effects, tell your doctor.

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the discovry of minoxidil molecule

The use of minoxidil for hair loss has an important history. It was first used during the 1970 as an oral medication for refractory cases of high blood pressure. The molecule is a piperidinopyrimidine derivative, with the chemical structure 2,6-diamino- 4-piperidinopyrimidine 1-oxide .

 It serves as an arteriolar vasodilator, acting specifically to open potassium channels. It also was found to have a side effect of hypertrichosis. , it was found to cause unwanted hair growth in 24% to 100%  of patients. Hypertrichosis was also noted in 5 out of 6 patients treated with minoxidil.  hypertrichosis is observed in a high frequency and at lower doses in women than in men No endocrine abnormalities have been associated, but darkening of the skin and the coarsening of facial features have been reported from long-term oral use.

Hypertrichosis caused by minoxidil was not reported in the dermatology literature until 1979 That same year, the oral tablet form, Loniten (Pharmacia & Upjohn, Bridgewater, NJ), was approved by the FDA for hypertension. Other dermatologists quickly took note in considering it for use in treating different forms of hair loss. Zapacosta  noted a reversal of androgenetic alopecia (AGA) in a patient receiving oral minoxidil. However, there were limitations to using the oral formulation, because it could cause an unsafe drop in blood pressure. Patients also experienced side effects of severe water retention and weight gain, often requiring concomitant treatment with a diuretic.

Therefore, several researchers tested its use as a topical formulation for hair loss. Two controlled trials using 1% topical minoxidil for alopecia areata (AA) demonstrated cosmetically acceptable regrowth in approximately half of patients. In 1984, topical minoxidil was used for the treatment of AGA. Five patients with AGA and 10 with AA were randomized to 1% or 5% topical minoxidil or placebo. Regrowth was seen in the 3 patients with AGA who were given the 5% solution, suggesting a clinical dose response. Blood levels of minoxidil were 0.5, 2.0, and 4.5 ng/mL 2 hours after application to the scalp. None of the patients with AA regrew hair, despite comparable blood levels.